Science

Expertise and special competencies

  • Biomechanics (experimental and theoretical)
  • Neurogastroenterology and mechanosensation
  • Founded the research center Mech-Sense
  • Research director at Aalborg Hospital in 2001 with the prime responsibility to qualify the hospital to become a university teaching hospital.
  • Served on a number of funding committees
  • Served on several editorial boards

Current research interests

Gastrointestinal motility. Visceral motor and sensory function. Electromechanical coupling in the intestine. Soft tissue mechanics and function. GI remodeling during functional and organic disease. The zero-stress state of biological tissues. Relation between morphology and mechanical strength. Modeling. Submucosal tissue as a smart biomaterial for implantation. Strain softening. Multi-layered composite models. Mechanosensory transduction. Diagnostic device development.

Scientific publications

Publication statistics from ISI
Top thirty scientific papers:

  1. Gregersen H, Kraglund K, Djurhuus JC. Variations in duodenal cross-sectional area during the interdigestive migrating motility complex. Am J Physiol 1990;259 (Gastrointest Liver Physiol 22):G26-G31.
  2. Tøttrup A, Knudsen M, Gregersen H. The role of the L-arginine-nitric oxide pathway in relaxation in the opossum lower esophageal sphincter. Br J Pharmacol 1991;104:113-6.
  3. Gregersen H, Jørgensen CS, Dall FH, Jensen SL. Characteristics of spontaneous and evoked motility in the isolated perfused porcine duodenum. J Appl Physiol 1992;73:9-19.
  4. Gregersen H, Giversen IM, Rasmussen LM, Tøttrup A. Biomechanical wall properties and collagen content in the partially obstructed opossum esophagus. Gastroenterology 1992;103:1547-51.
  5. Gregersen H, Orvar K, Christensen J. Biomechanical properties of duodenal wall and duodenal tone during phase I and phase II of the MMC. Am J Physiol 1992;263 (Gastrointest Liver Physiol 26): G795-G801.
  6. Dall FH, Jørgensen CS, Houe D, Gregersen H, Djurhuus JC. Biomechanical wall properties of the human rectum. A study with impedance planimetry. Gut 1993;34:1581-6.
  7. Rao SSC, Gregersen H, Hayek B, Summers RV, Christensen J. Unexplained chest pain: The hypersensitive, hyperreactive and poorly compliant esophagus. Ann Int Med 1996;124:950-8.
  8. Gregersen H, Kassab GS. Biomechanics of the gastrointestinal tract. Neurogastroenterol Motil 1996;8:277-97.
  9. Gregersen H, Kassab GS, Pallencoea E, Lee C, Chien S, Skalak R, Fung UC. Morphometry and strain distribution in guinea-pig duodenum with reference to the zero-stress state. Am J Physiol 1997;273:G865-G874.
  10. Gregersen H, Emery J, McCulloch AD. History-dependent mechanical behaviour of the guinea-pig small intestine. Ann Biomed Eng 1998;26:1-9.
  11. Frøbert O, Gregersen H, Bjerre J, Bagger JP, Kassab GS. Relation between the zero-stress state of the porcine left coronary arterial tree and its branching order. Am J Physiol 1998;(Heart Circ Physiol 44):H2283-H2290.
  12. Lu X. Zhao JB, Wang GR, Gregersen H, Kassab GS. Remodeling of the zero-stress state of femoral arteries in response to flow overload. Am J Physiol (Heart Circ Physiol) 2001;280:H1547-H1559.
  13. Zhao J, Day J, Zhuang FY, Gregersen H. Regional arterial stress-strain distributions reference to the zero-stress state in the rat. Am J Physiol 2002;282:H622-H629.
  14. Drewes AM, Schipper K-P, Dimcevski G, Petersen P, Andersen OK, Gregersen H, Arendt-Nielsen L. Multimodal assessment of pain in the esophagus – a new experimental model. Am J Physiol Gastrointest Liver Physiol 2002;283:G95-G103.
  15. Gregersen H, Gilja OH, Hausken T, Heimdal A, Gao C, Matre K, Ødegaard S, Berstad A. Mechanical properties in the human gastric antrum using B-mode ultrasonography and antral distension.  Am J Physiol 2002;283:G368-G375.
  16. Pedersen J, Gao C, Egekvist H, Bjerring P, Arendt-Nielsen L, Gregersen H, Drewes AM. Pain and biomechanical responses to distention of the duodenum in patients with systemic sclerosis. Gastroenterology 2003; 124: 1230-39.
  17. Zhao J, Yang J, Gregersen H. Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats. Diabetologia 2003;46:1688-1697.
  18. Dang Q, Gregersen H, Duch B, Kassab GS. Indicial Response Functions of Growth and Remodeling of common Bile Duct Post Obstruction. Am J Physiol (Gastrointest Liver Physiol) 2004; 286 (3):G420-7.
  19. Li ZJ, Huang W, Jiang Z, Gregersen H, Fung YC. Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension. Proceedings of the National Academy of Science 2004; 101(31):11488-93.
  20. Yang J, Liao D, Zhao J, Gregersen H. Shear modulus of elasticity of the esophagus. Ann Biomed Eng 2004;32(9):1223-30.
  21. Kassab GS, Lontis ER, Horlyck A, Gregersen H. Novel method for measurement of medium size arterial lumen area with an impedance catheter: in vivo validation. Am J Physiol Heart Circ Physiol 2005; 288(4):H2014-20.
  22. Gregersen H, Drewes AM, Gilja OH. Tension receptors. Theoretical construct or fact? Gastroenterology 2005;128:803-804.
  23. Gregersen H, Christensen J: Mechanically restricted regional blood flow might explain gastrointestinal pain. Nature - Gastroenterology and Hepatology 2005;2:378-9.
  24. Gregersen H, Hausken T, Yang J, Odegaard S, Gilja OH. Mechanosensory properties in the human gastric antrum evaluated using B-mode ultrasonography during volume-controlled antral distension. Am J Physiol  2006; maj; 29; G876-G882
  25. Drewes AM, Reddy H, Pedersen J, Funch-Jensen P, Gregersen H, Arendt-Nielsen L. Multimodal pain stimulations in patients with grade B oesophagitis. Gut. 2006; 55; 926-932. Choose billig louboutin schuhe online.
  26. McMahon BP, Frøkjær JB, Kunwald P, Donghua L, Funch-Jensen P, Drewes AM, Gregersen H. The Functional Lumen Imaging Probe (FLIP) for Evaluation of the Esophagogastric Junction. American Journal of Physiology. 2007; 292; G377-G384.
  27. Sevcencu C, Pennisi CP, Yoshida K, Gregersen H. Simultaneous monitoring of cellular depolarization and contraction - a new method to investigate excitability and contractility in isolated smooth muscle cells. American J Physiol (Gastrointest Liver Physiol) 2008, March, 294 (3) ;G648-G654, 2008.
  28. Munk EM, Noergaard B, Dethlefsen C, Gregersen H, Drewes AM, Funch-Jensen P, Soerensen HT. Unexplained Chest/Epigastric Pain in Patients with Normal Endoscopy as a Predictor for Ischemic Heart Disease and Mortality: A Danish 10-Year Cohort Study. BMC Gastroenterology 2008, 8:28.
  29. Fenner JW, Brook B, Clapworthy G, Coveney PV, Feipel V, Gregersen H, Hose DR, Kohl P, Lawford P, McCormack  KM, Pinney D, Thomas SR, Van Sint Jan S, Waters S, Viceconti M. The EuroPhysiome, STEP and a Roadmap for the Virtual Physiological Human. Philosophical Transactions A Math Phys Eng. Sci. September 13, 2008;366(1878):2979-99.
  30. Dinning PG, Arkwright JW, Gregersen H, O’Grady G, Scott SM. Technical advances in monitoring human motility patterns. Neurogastroenterology & Motility. 2010 Feb; 22, 366–380

Books

  1. Jensen SL, Gregersen H, Amiri MS, Moody FM (eds.): Essentials of Experimental Surgery. Gastroenterology. Harwood Academic Publishers. 57 chapters, 800 pages. Published March 1996. ISBN 3-7186-5496-2.
  2. Gregersen H. Biomechanics of the Gastrointestinal Tract. Springer-Verlag. London 2002. ISBN 1852335203.
  3. Gregersen H, Drewes AM. Center of Excellence in Visceral Biomechanics and Pain. Aalborg Hospital Publications. 2003. ISBN 87-90880-12-9.
  4. Ødegaard S, Gilja OH, Gregersen H. Basic and New Aspects of Gastrointestinal Ultrasonography. World Scientific Publishers. 2005. ISBN 981-238-845-1
  5. Gregersen H. Biomechanics of the Gastrointestinal Tract. Springer Verlag 2006 (Chinese version of the 2002 English edition)
  6. Viceconti, Gregersen and STEP Consortium. Seeding the EuroPhysiome: A roadmap to the virtual physiological human. www.europhysiome.org. 105 pages.

Fundraising

Funding as principal investigator from EU FP6 (STEP) and FP7 (DIAMARK), National Institute of Health, the Danish Research Councils, the Danish Heart Foundation, Obels Fond and many other foundations in the past 20 years.

Member of funding committeesards

Aalborg Hospital Research Funds
2001-2010
The Danish Medical Associations Research Fund
2003-2009
The Research Initiative,
Aarhus University Hospital
2004-2010
Karen Elise Jensens Foundation 2005-
The Clinical Institute, Aarhus University 2005-2010
Aalborg Fonden 2007-2010
Hertha Christensens Fond 2007-2010

Editorial boards

1995
Editorial board member. Surgical Research Communications
2001-2010
Editor on the annual report from Aalborg Hospital
2004-2006 Editorial board member of World Journal of Gastroenterology
2006- Permanent member of the scientific panel of O.E.S.O.
2007- Editorial board member. Neurogastroenterology and Motility
2008- Associate Editor. Journal of Biomechanical Engineering
2008- Editorial board. International Journal of Experimental and Computational Biomechanics
2009- Editorial board member. The American Journal of Physiology: Gastrointestinal and Liver Physiology

Awards

Eight research awards among them the prestigious Walton Award in 2006 named after the Irish Nobel laureate in physics ETS Walton and the American Gastroenterology Association Award in 2008 for scientific achievements.